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KMID : 1123920220360010023
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Korean Journal of Oriental Physiology and Pathology
2022 Volume.36 No. 1 p.23 ~ p.27
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Effect of the Extract of Stachys Affinis on DNFB-induced Allergic Contact Dermatitis in Mice
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Lee Yun-Seong
Jeong Sun-Oh
Pae Hyun-Ock
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Abstract
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This study aims to evaluate the anti-inflammatory effect of 80% ethanol extracts of Stachys affinis (MQ) on 1-fluoro-2,4-Dinitrofluorobenzene (DNFB) induced atopic dermatitis (AD) in Balb/c mice. AD-like allergic contact dermatitis was induced by challenge of DNFB on the ear after DNFB sensitization on the back sides of mice. MQ alleivated clinical severity in AD-like skin lesions. In addition, ear thickness of epidermis and penetration of inflammatory cells in AD-like skin lesions were decreased by topical application of MQ. The the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were measured in AD mice using ELISA kits. Levels of TNF-α and IL-4 in serum were significantly decreased by topical application of MQ. Therefore, this study could give a clinical basis that MQ could be a agent to prevent AD.
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KEYWORD
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Stachys affinis, Atopic dermatitis, 1-fluoro-2, 4-Dinitrofluorobenzene, Cytokines, Skin inflammation
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